Opportunity Information: Apply for RFA AT 20 004
The HEAL Initiative PRISM funding opportunity (RFA-AT-20-004) is a National Institutes of Health cooperative agreement designed to support large-scale, real-world research that improves pain management while reducing reliance on opioid prescribing. It uses a phased UG3/UH3 structure, meaning applicants submit one combined application that covers both a one-year planning period (UG3) and a subsequent implementation period (UH3). The UG3 year is milestone-driven and focused on proving that the proposed pragmatic trial or implementation study can actually be carried out as intended in routine care; only projects that meet clearly defined feasibility and scientific milestones are eligible to transition into the UH3 phase, where the full study is executed.
The core purpose of PRISM is practical impact at the health care system level. The FOA emphasizes pragmatic trial designs and implementation science approaches that can work under typical conditions, not tightly controlled research environments. A central requirement is that the intervention being tested is embedded in health care delivery, meaning it must be integrated into real clinical workflows, real settings, and real patient populations. Applicants may propose to scale interventions that already have evidence of efficacy and adapt them for use across health systems, or they may propose system-level changes that improve adherence to evidence-based pain care guidelines. In either case, the expectation is that the study will generate results that health systems can use quickly and broadly, with a clear line of sight to reducing unnecessary opioid exposure while still managing pain effectively.
Another defining feature is that projects must be conducted across at least two or more distinct health care systems, not within a single institution. This multi-system requirement is meant to strengthen generalizability and ensure that findings are relevant beyond one local context. Additionally, studies funded under this FOA must be carried out as part of the NIH Health Care Systems Research Collaboratory, a Common Fund effort focused on improving the way embedded pragmatic clinical trials are done in partnership with delivery systems. As part of that structure, awardees work closely with the Collaboratory Coordinating Center, which provides technical expertise and operational support for issues that commonly arise in embedded research, such as stakeholder engagement, workflow integration, electronic health record-enabled research, data harmonization, ethics and regulatory considerations, and strategies for rapid execution at scale. NIH and the Coordinating Center are not passive funders here; because this is a cooperative agreement, there is an expectation of active collaboration to help ensure trials are feasible, well-run, and positioned for high impact.
In terms of who can apply, eligibility is broad and spans many organization types, including state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities; nonprofit organizations with or without 501(c)(3) status; and for-profit organizations (including small businesses). This wide eligibility reflects the reality that effective pain management and opioid stewardship involves multiple sectors, and strong applications often depend on tight partnerships between researchers and operational leaders within health systems.
Administratively, the opportunity is listed under the U.S. Department of Health and Human Services and NIH, with multiple CFDA numbers tied to different NIH components. It was originally posted with a creation date of January 23, 2020 and an original closing date of March 30, 2020, and it anticipated a small number of awards (two). The award ceiling is shown as zero in the listing, which usually indicates that the ceiling is not specified in that particular summary record rather than implying that no funds are available. Overall, the FOA is aimed at producing actionable, system-level evidence about how to deliver better pain care while reducing opioid prescribing, using research designs that fit into everyday health care delivery and can be replicated across diverse health systems.Apply for RFA AT 20 004
- The Department of Health and Human Services, National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.213, 93.307, 93.350, 93.361, 93.393, 93.846, 93.865.
- This funding opportunity was created on Jan 23, 2020.
- Applicants must submit their applications by Mar 30, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| BRAIN Initiative: Exploratory Team-Research BRAIN Circuit Programs - eTeamBCP (U01 Clinical Trials Optional) Apply for RFA NS 20 029 Funding Number: RFA NS 20 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Martin Delaney Collaboratory for Pediatric HIV Cure Research (UM1 Clinical Trial Not Allowed) Apply for RFA AI 20 036 Funding Number: RFA AI 20 036 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $3,500,000 |
| BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed) Apply for RFA EB 20 002 Funding Number: RFA EB 20 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
| Emergency Awards: Automatic Detection and Tracing of SARS-CoV-2 (U01 Clinical Trial Not Allowed) Apply for RFA OD 20 014 Funding Number: RFA OD 20 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Emergency Awards RADx-RAD: Screening for COVID-19 by Electronic-Nose Technology (SCENT) (U18 Clinical Trial Not Allowed) Apply for RFA OD 20 017 Funding Number: RFA OD 20 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed) Apply for RFA NS 21 013 Funding Number: RFA NS 21 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Planning Projects TargetedBCPP (R34 Clinical Trials Not Allowed) Apply for RFA NS 21 014 Funding Number: RFA NS 21 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $225,000 |
| Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03) Apply for PAR 16 348 Funding Number: PAR 16 348 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01) Apply for RFA MH 17 220 Funding Number: RFA MH 17 220 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Non-Invasive Neuromodulation - Mechanisms and Dose/Response Relationships for Targeted CNS Effects (R01) Apply for RFA MH 17 245 Funding Number: RFA MH 17 245 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01) Apply for RFA MH 17 240 Funding Number: RFA MH 17 240 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Fellows: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) Apply for RFA MH 17 250 Funding Number: RFA MH 17 250 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Data Archives for the BRAIN Initiative (R24) Apply for RFA MH 17 255 Funding Number: RFA MH 17 255 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Standards to Define Experiments Related to the BRAIN Initiative (R24) Apply for RFA MH 17 256 Funding Number: RFA MH 17 256 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Integration and Analysis of BRAIN Initiative Data (R24) Apply for RFA MH 17 257 Funding Number: RFA MH 17 257 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (U01) Apply for RFA NS 17 003 Funding Number: RFA NS 17 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01) Apply for RFA NS 17 004 Funding Number: RFA NS 17 004 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44) Apply for RFA NS 17 007 Funding Number: RFA NS 17 007 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3) Apply for RFA NS 17 006 Funding Number: RFA NS 17 006 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3) Apply for RFA NS 17 005 Funding Number: RFA NS 17 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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