Opportunity Information: Apply for PAR 21 127
The Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed), Funding Opportunity Number PAR-21-127, is a National Institutes of Health (NIH) grant program within the U.S. Department of Health and Human Services. It is designed to help NIH-supported research communities at eligible organizations obtain access to major, high-cost scientific instrumentation by funding the purchase or upgrade of a single, specialized, commercially available instrument or an integrated instrumentation system. The core idea is shared access: rather than supporting instruments for one lab, the program emphasizes a group of investigators who will collectively use and benefit from the equipment to advance NIH-relevant biomedical and behavioral research.
This opportunity supports capital equipment needs that are often too expensive for individual projects or single-lab budgets, but that can significantly expand research capability when made available as a shared resource. The types of instruments that can be supported are broad and include, among others, X-ray diffractometers, mass spectrometers, nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imaging systems. In practice, these are the kinds of platforms that frequently anchor core facilities or shared resource centers, enabling multiple research teams to perform sophisticated measurements, imaging, characterization, and high-throughput analyses.
The award has a minimum request amount of $50,000 and a maximum award ceiling of $600,000. While there is no maximum price limit for the instrument itself, NIH will not award more than $600,000 under this program, meaning institutions may need to cover any remaining cost if an instrument exceeds the cap. The funding instrument type is a grant, and the program sits within NIH health-related funding activity categories. The opportunity is listed under CFDA numbers 93.351 and 93.859, reflecting its placement within NIH assistance programs.
Eligibility includes a range of U.S.-based organizations that commonly host NIH-funded research, such as public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) entities that meet NIH eligibility rules). The listing also notes “Others” with additional eligibility details in the full announcement, which typically clarifies any special institutional categories or requirements.
Administratively, the opportunity was created February 8, 2021, with an original closing date of June 1, 2021, and it anticipated making about 75 awards. Finally, the “Clinical Trial Not Allowed” label means the grant mechanism is not intended to support clinical trial activities; the focus is on shared instrumentation acquisition or upgrade to support research programs rather than funding clinical interventions or trial conduct.Apply for PAR 21 127
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351, 93.859.
- This funding opportunity was created on Feb 08, 2021.
- Applicants must submit their applications by Jun 01, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- The number of recipients for this funding is limited to 75 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed) - FAQs
What is the Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)?
The Shared Instrumentation Grant (SIG) Program is an NIH grant opportunity (Funding Opportunity Number PAR-21-127) within the U.S. Department of Health and Human Services. It supports the purchase or upgrade of a single, specialized, commercially available scientific instrument or an integrated instrumentation system intended for shared use by a group of investigators conducting NIH-relevant biomedical and behavioral research.
What is the main purpose of this grant?
The main purpose is to expand research capability by funding access to major, high-cost scientific instrumentation that is typically too expensive for individual projects or single labs, but highly impactful when operated as a shared resource for multiple NIH-supported investigators.
Does the program emphasize individual lab ownership or shared access?
The program emphasizes shared access. The core idea is that the instrument serves a group of investigators who will collectively use and benefit from the equipment as a shared resource rather than supporting a single lab.
What kinds of purchases are supported (purchase vs. upgrade)?
The opportunity supports either the purchase of a single, specialized, commercially available instrument or the upgrade of an existing instrument. It can also support an integrated instrumentation system, as long as it is treated as a single system for shared use.
Is this funding intended to support research projects directly?
Based on the description provided, the funding is intended to support acquisition or upgrade of shared instrumentation that enables research. The focus is on capital equipment access for NIH-supported research communities rather than funding individual research project activities.
What types of instruments can be supported?
The types are broad. Examples listed include X-ray diffractometers, mass spectrometers, nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imaging systems.
Are core facilities or shared resource centers relevant to this program?
Yes. The description notes that these instruments often anchor core facilities or shared resource centers and enable multiple research teams to access sophisticated measurement, imaging, characterization, and high-throughput analysis capabilities.
What is the minimum amount that can be requested?
The minimum request amount is $50,000.
What is the maximum amount NIH will award under this opportunity?
The maximum award ceiling is $600,000. NIH will not award more than $600,000 under this program.
Is there a maximum price limit for the instrument itself?
No maximum instrument price limit is stated. However, NIH will not award more than $600,000, so if the instrument costs more than $600,000, the institution may need to cover the remaining cost.
What type of funding instrument is used?
The funding instrument type is a grant.
Which federal agency administers this opportunity?
The opportunity is a National Institutes of Health (NIH) program within the U.S. Department of Health and Human Services.
What is the Funding Opportunity Number?
The Funding Opportunity Number is PAR-21-127.
What does the label "S10 Clinical Trial Not Allowed" mean?
It means the grant mechanism is not intended to support clinical trial activities. The stated focus is on shared instrumentation acquisition or upgrade to support research programs, rather than funding clinical interventions or the conduct of trials.
Who is eligible to apply?
Eligibility includes U.S.-based organizations commonly hosting NIH-funded research, including public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities that meet NIH eligibility rules). The listing also notes "Others" with additional details typically provided in the full announcement.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are included, including 501(c)(3) and certain non-501(c)(3) nonprofits that meet NIH eligibility requirements.
Are institutions of higher education eligible?
Yes. Both public/state-controlled institutions of higher education and private institutions of higher education are listed as eligible organization types.
What does "Others" mean in the eligibility section?
The listing indicates there are additional eligibility details in the full announcement. In practice, this usually clarifies special institutional categories or requirements, but the specific details are not included in the provided summary.
Which CFDA numbers are associated with this opportunity?
The opportunity is listed under CFDA numbers 93.351 and 93.859.
When was this opportunity created?
The opportunity was created on February 8, 2021.
What was the original closing date?
The original closing date was June 1, 2021.
How many awards were anticipated?
The opportunity anticipated making about 75 awards.
Is the instrument required to be commercially available?
Yes. The description specifies that the supported instrument or integrated instrumentation system is "commercially available."
Is the grant limited to one instrument or can it support multiple separate instruments?
The description states it funds the purchase or upgrade of a single, specialized instrument or an integrated instrumentation system. It does not describe support for multiple separate, unrelated instruments.
What research areas does the supported instrumentation need to serve?
The instrumentation is intended to support NIH-relevant biomedical and behavioral research and benefit NIH-supported research communities at eligible organizations.
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