Opportunity Information: Apply for PAS 21 031
The grant opportunity titled "Priority HIV/AIDS Research within the Mission of the NIDDK (R01 Clinical Trial Optional)" (Funding Opportunity Number PAS-21-031) is a discretionary NIH research grant designed to expand and strengthen HIV/AIDS research that fits squarely within the scientific mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). In practical terms, it is meant to encourage investigators to propose HIV-related studies that connect to NIDDKs core areas, including diabetes and other endocrine/metabolic diseases, digestive and liver diseases, nutrition and obesity, and kidney/urologic/hematologic conditions. The emphasis is not HIV research in the broadest sense, but HIV/AIDS research that advances understanding, prevention, treatment, or management of HIV-associated issues that overlap with NIDDK-relevant biology, organ systems, comorbidities, and clinical care needs.
A central requirement is alignment with the NIH Office of AIDS Research (OAR) priorities and guidelines for HIV/AIDS funding, most recently summarized in the NIH notice NOT-OD-20-018, "UPDATE NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding." Applicants are expected to shape their projects so they clearly map to those NIH-wide HIV/AIDS priorities while also remaining within NIDDKs scope. This dual alignment matters because the FOA is positioned as a way to stimulate targeted HIV/AIDS research that complements broader NIH strategy, rather than duplicating work outside the institute mission or outside the OAR priority framework.
The mechanism is an R01, meaning it supports a substantial, hypothesis-driven research project (or cohesive set of related aims) with enough scope to generate major advances in knowledge and, where relevant, clinical practice. The "Clinical Trial Optional" designation indicates that applicants may propose studies that include a clinical trial, but they are not required to do so; both clinical trial and non-clinical trial applications can be responsive if they meet the scientific and programmatic goals. This is important for teams working across the translational spectrum, from fundamental mechanistic studies that inform HIV-associated metabolic or renal complications, to patient-oriented research that tests interventions or strategies relevant to NIDDK disease domains in people with HIV.
Eligibility is broad and includes many types of U.S. and non-U.S. institutions and organizations. Standard eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) IRS status (excluding institutions of higher education in those nonprofit categories); for-profit organizations (other than small businesses); and small businesses. The announcement also explicitly highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It further includes faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations), reflecting an intent to encourage participation from diverse institutional settings and communities, including those disproportionately affected by HIV.
The sponsoring agency is the National Institutes of Health, and the listed activity category is Food and Nutrition, Health, with CFDA number 93.847. The FOA was created on 2021-01-08, and the original closing date shown is 2024-01-07. While the provided source data does not specify an award ceiling or the expected number of awards, the R01 format typically supports well-justified budgets appropriate to the scope of work, subject to NIH and institute policies and to the scientific merit of the application.
Overall, this opportunity is best understood as an NIH pathway for investigators who can make a clear case that their HIV/AIDS-related questions are inseparable from, and highly impactful for, NIDDK-relevant health conditions. Strong applications will usually articulate (1) the HIV/AIDS significance and how it fits OAR priorities, (2) the specific NIDDK-mission relevance such as metabolic, digestive, nutritional, kidney, or related comorbidity impacts, and (3) a rigorous research plan appropriate for an R01, with or without a clinical trial component.Apply for PAS 21 031
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Priority HIV/AIDS Research within the Mission of the NIDDK (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2021-01-08.
- Applicants must submit their applications by 2024-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Priority HIV/AIDS Research within the Mission of the NIDDK (R01 Clinical Trial Optional) (PAS-21-031)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Priority HIV/AIDS Research within the Mission of the NIDDK (R01 Clinical Trial Optional)" and the Funding Opportunity Number is PAS-21-031.
What type of grant mechanism is this?
This is an NIH R01 research grant. An R01 generally supports a substantial, hypothesis-driven research project (or a cohesive set of related aims) intended to produce meaningful advances in scientific knowledge and, when relevant, clinical practice.
What is the main purpose of this funding opportunity?
The purpose is to expand and strengthen HIV/AIDS research that fits squarely within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It encourages HIV-related studies that directly connect to NIDDK core areas rather than HIV research in the broadest sense.
Which scientific areas does NIDDK emphasize for this HIV/AIDS-focused R01?
Responsive projects are expected to align with NIDDK-relevant biology, organ systems, comorbidities, and clinical care needs, including:
- Diabetes and other endocrine/metabolic diseases
- Digestive and liver diseases
- Nutrition and obesity
- Kidney, urologic, and hematologic conditions
Is this opportunity meant to fund any HIV/AIDS research topic?
No. The emphasis is on HIV/AIDS research that advances understanding, prevention, treatment, or management of HIV-associated issues that overlap with NIDDK-relevant disease areas (metabolic, digestive, nutritional/obesity, kidney/urologic/hematologic) and related clinical needs.
What does "Clinical Trial Optional" mean for this FOA?
"Clinical Trial Optional" means applicants may propose research that includes a clinical trial, but they are not required to. Both clinical trial and non-clinical trial applications can be responsive as long as they meet the scientific and programmatic goals described for NIDDK-mission-aligned HIV/AIDS research.
Do applicants have to align with NIH-wide HIV/AIDS priorities?
Yes. A central requirement is alignment with the NIH Office of AIDS Research (OAR) priorities and guidelines for HIV/AIDS funding. Applicants are expected to map their project clearly to those NIH-wide HIV/AIDS priorities while also staying within NIDDK scope.
Which NIH notice is referenced for HIV/AIDS priorities and funding guidelines?
The information provided references NIH notice NOT-OD-20-018, titled "UPDATE NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding."
Why is dual alignment (OAR priorities and NIDDK mission) important?
This FOA is positioned to stimulate targeted HIV/AIDS research that complements the broader NIH strategy (via OAR priorities) and remains within NIDDK's mission. Applications are expected to show both kinds of alignment to avoid proposing work outside the institute mission or outside the OAR priority framework.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
Which NIH institute is the focus of this opportunity?
The opportunity is focused on research within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the activity category and CFDA number listed for this opportunity?
The listed activity category is Food and Nutrition, Health, and the CFDA number is 93.847.
When was this funding opportunity created?
The FOA was created on 2021-01-08.
What is the closing date shown in the provided information?
The original closing date shown is 2024-01-07.
Is the award ceiling or number of awards provided?
No. The provided source data does not specify an award ceiling or the expected number of awards.
What does the R01 format imply about the project scope and budget?
Based on the provided description, the R01 format typically supports well-justified budgets appropriate to the scope of work, subject to NIH and institute policies and to the scientific merit of the application.
Are clinical and translational projects both appropriate under this FOA?
Yes. The description highlights responsiveness across the translational spectrum, from fundamental mechanistic studies informing HIV-associated metabolic or renal complications to patient-oriented research testing interventions or strategies relevant to NIDDK disease domains in people with HIV.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. institutions and organizations. Examples listed include:
- State, county, and local governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Tribal organizations other than federally recognized governments
- Public housing authorities and Indian housing authorities
- Nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories)
- For-profit organizations (other than small businesses)
- Small businesses
- Faith-based or community-based organizations
- Eligible federal agencies
- Regional organizations
- U.S. territories or possessions
- Non-domestic (non-U.S.) entities (foreign organizations)
Does the FOA explicitly encourage applications from certain institution types?
Yes. The announcement explicitly highlights eligibility for, among others, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility information provided includes non-domestic (non-U.S.) entities (foreign organizations).
What general qualities would a strong application typically include according to the description?
Strong applications will usually articulate three things clearly:
- The HIV/AIDS significance and how the project fits OAR priorities
- The specific relevance to NIDDK's mission (for example, metabolic, digestive, nutritional/obesity, kidney, or related comorbidity impacts)
- A rigorous research plan appropriate for an R01, with or without a clinical trial component
Is this FOA discretionary?
Yes. The opportunity is described as a discretionary NIH research grant.
What is the overall "best fit" for applicants considering this opportunity?
It is best suited for investigators who can make a clear case that their HIV/AIDS-related research questions are inseparable from, and highly impactful for, NIDDK-relevant health conditions (metabolic, digestive, nutritional/obesity, kidney/urologic/hematologic, and related comorbidities and clinical care needs).
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| Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of the NIDDK (R21 Clinical Trial Not Allowed) Apply for PAR 21 062 Funding Number: PAR 21 062 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Biomarkers for Diabetic Foot Ulcers through the Diabetic Foot Consortium (R61/R33 Clinical Trial Not Allowed) Apply for RFA DK 21 001 Funding Number: RFA DK 21 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $325,000 |
| Immune Cell Engineering For Targeted Therapy And Disease Monitoring in Type 1 Diabetes (R01 Clinical Trial Not Allowed) Apply for RFA DK 21 005 Funding Number: RFA DK 21 005 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| New Directions in Hematology Research (SHINE-II) (R01 Clinical Trial Optional) Apply for PAS 21 150 Funding Number: PAS 21 150 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| The Autoantigens and Neoantigens Function in the Etiology and Pathophysiology of Type 1 Diabetes (R01 Clinical Trial Optional) Apply for RFA DK 21 004 Funding Number: RFA DK 21 004 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Program to Advance the Career Development of Scientists from Diverse Backgrounds Conducting Nutrition, Obesity, Diabetes, and Related Research (U24 Clinical Trial Optional) Apply for RFA DK 20 034 Funding Number: RFA DK 20 034 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Nutrition Obesity Research Centers (P30 Clinical Trial Optional) Apply for RFA DK 21 015 Funding Number: RFA DK 21 015 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (T1D) (R01 Clinical Trial Optional) Apply for RFA DK 21 006 Funding Number: RFA DK 21 006 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Kidney Precision Medicine Project Central Hub (U24 Clinical Trial Not Allowed) Apply for RFA DK 20 029 Funding Number: RFA DK 20 029 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Kidney Precision Medicine Project Tissue Interrogation Sites (U01 Clinical Trial Not Allowed) Apply for RFA DK 20 028 Funding Number: RFA DK 20 028 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Kidney Precision Medicine Project Recruitment Sites (U01 Clinical Trial Not Allowed) Apply for RFA DK 20 026 Funding Number: RFA DK 20 026 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Kidney Precision Medicine Project Kidney Tissue Atlas Coordinating Center (U01 Clinical Trial Not Allowed) Apply for RFA DK 20 027 Funding Number: RFA DK 20 027 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Short-Term Research Experience Program to Unlock Potential (STEP-UP) (R25 Clinical Trial Not Allowed) Apply for RFA DK 21 023 Funding Number: RFA DK 21 023 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Support for Small Business Innovation Research (SBIR) to Develop New Technologies for Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R43/R44 Clinical Trial Not Allowed) Apply for RFA DK 21 011 Funding Number: RFA DK 21 011 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Comprehensive Care for Adults with Type 2 Diabetes Mellitus from Populations with Health Disparities (R01 Clinical Trial Optional) Apply for PA 21 232 Funding Number: PA 21 232 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Characterization of Islet-derived Extracellular Vesicles for Improved Detection, Monitoring, Classification, and Treatment of Type 1 Diabetes (R01 Clinical Trial Not Allowed) Apply for RFA DK 21 016 Funding Number: RFA DK 21 016 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Support for Small Business Innovation Research (SBIR) to Develop New Methods and Technologies for Assessment of Risk and for Early Diagnosis and Prognosis of Type 1 Diabetes (R43/R44 Clinical Trial Not Allowed) Apply for RFA DK 21 021 Funding Number: RFA DK 21 021 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Identification and Characterization of Bioactive Microbial Metabolites for Advancing Research on Microbe-Diet-Host Interactions Knowledgebase Management Center (U24 Clinical Trial Not Allowed) Apply for RFA DK 21 014 Funding Number: RFA DK 21 014 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed) Apply for RFA DK 21 002 Funding Number: RFA DK 21 002 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required) Apply for RFA HL 22 014 Funding Number: RFA HL 22 014 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
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