Opportunity Information: Apply for RFA CA 20 039
Emergency Awards: Research Projects in SARS-CoV-2 Serological Sciences (U01 Clinical Trial Optional) is a National Institutes of Health funding opportunity led by the National Cancer Institute and released as part of the COVID-19 supplemental funding provided under the Paycheck Protection Program and Health Care Enhancement Act (P.L. 116-139). The program is designed to rapidly strengthen the nations capacity to develop, validate, improve, and implement SARS-CoV-2 serological tests and the supporting technologies needed to use those tests reliably in research and public health settings. The award mechanism is a U01 cooperative agreement, which typically means NIH staff will have substantial scientific involvement during the project period rather than operating strictly as a hands-off grant.
The core purpose of the FOA is to stand up Serological Sciences Research Projects that push forward what serology can tell us about COVID-19 and immunity. The research scope is broad but focused on practical gaps that mattered during the pandemic response: characterizing immune responses after SARS-CoV-2 infection; clarifying the mechanisms behind serological, humoral, and cellular immune responses; identifying how host factors such as genetics and environment modify immune responses; and determining serological correlates that relate to disease severity, pathogenesis, and protection against future infection. In addition to lab and immunology science, the FOA also highlights real-world implementation needs, specifically research that defines barriers to access, communication, and uptake of SARS-CoV-2 serological testing, recognizing that even excellent tests can fall short if people cannot obtain them, understand them, or trust how results are used.
Funded U01 projects are intended to operate as part of a larger, coordinated Serological Sciences Network (SeroNet). This network model is central to the opportunity: awardees are not expected to work in isolation, but to collaborate, share, and align methods so that outputs can be compared and combined across sites. SeroNet includes multiple complementary components beyond these U01 projects, including Serological Sciences Centers of Excellence funded through a companion U54 announcement (RFA-CA-20-038), a serology laboratory at the Frederick National Laboratory for Cancer Research (FNLCR), Serological Capacity Building Centers, and a Serological Sciences Network Coordinating Center. The coordinating functions are managed through FNLCR, which is a federally funded research and development center, and the broader ecosystem could also include SBIR awards and other serology-related grants and contracts. Across all components, the FOA emphasizes collaboration, including sharing data, results, and reagents to accelerate progress and reduce duplication.
Eligibility is expansive across the U.S. research and public sector landscape. Eligible applicants include state, county, city, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; federally recognized tribal governments; and tribal organizations that are not federally recognized, among others. The announcement also explicitly calls out participation from mission-relevant institutions and community-rooted organizations such as Historically Black Colleges and Universities, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, as well as faith-based and community-based organizations and U.S. territories or possessions. At the same time, the FOA draws clear lines around non-U.S. involvement: non-domestic (non-U.S.) entities and non-U.S. institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible. However, foreign components, as defined by NIH policy, are allowed, which can support specific international elements when justified and compliant.
Administratively, this opportunity is listed as RFA-CA-20-039, categorized as discretionary funding, and uses the cooperative agreement funding instrument. It is associated with CFDA numbers 93.394, 93.395, 93.396, and 93.855. The FOA was created on June 5, 2020, with an original application due date of July 22, 2020. While the provided listing does not specify an award ceiling or the expected number of awards, the structure and networked design signal an intent to fund multiple coordinated projects that together can standardize and scale serological science, improve the interpretability of immune markers, and translate testing advances into actionable knowledge for managing COVID-19 and future infectious disease threats.Apply for RFA CA 20 039
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Emergency Awards: Research Projects in SARS-CoV-2 Serological Sciences (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395, 93.396, 93.855.
- This funding opportunity was created on 2020-06-05.
- Applicants must submit their applications by 2020-07-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (RFA CA 20 039) also looked into and applied for these:
| Funding Opportunity |
|---|
| Emergency Awards: SARS-CoV-2 Serological Sciences Centers of Excellence (U54 Clinical Trial Optional) Apply for RFA CA 20 038 Funding Number: RFA CA 20 038 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Interventions to Prevent Electronic Nicotine Delivery Systems (ENDS) Use Among Adolescents (R01 - Clinical Trial Optional) Apply for RFA DA 21 009 Funding Number: RFA DA 21 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Regional Medical Libraries for the Network of the National Library of Medicine (UG4) Apply for RFA LM 20 001 Funding Number: RFA LM 20 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Large scale mapping and/or molecular profiling of ensembles and/or cell-types mediating opioid action in the rodent brain (R01 - Clinical Trial Not Allowed) Apply for PAR 20 241 Funding Number: PAR 20 241 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| 3D Technologies to Accelerate HTAN Atlas Building Efforts (UH2 Clinical Trial Not Allowed) Apply for RFA CA 20 042 Funding Number: RFA CA 20 042 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| PrEP for HIV Prevention among Substance Using Populations (R01 - Clinical Trial Optional) Apply for RFA DA 21 024 Funding Number: RFA DA 21 024 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Mentored Clinical Scientist Development Program Award in Substance Use and Substance Use Disorder Research (K12 Clinical Trial Optional) Apply for PAR 20 249 Funding Number: PAR 20 249 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed) Apply for RFA LM 20 002 Funding Number: RFA LM 20 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $610,000 |
| Aging, Cancer-Initiating Cells, and Cancer Development (U01 Clinical Trial Not Allowed) Apply for RFA CA 20 040 Funding Number: RFA CA 20 040 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Tobacco Use and HIV in Low and Middle-Income Countries (U01 Clinical Trial Optional) Apply for RFA CA 20 037 Funding Number: RFA CA 20 037 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Using Human Cell Animal Chimera Brains to Study HIV Latency and Pathology R01 - Clinical Trials Not Allowed Apply for RFA DA 21 026 Funding Number: RFA DA 21 026 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Promoting Research on Music and Health: Phased Innovation Award for Music Interventions (R61/R33 Clinical Trial Optional) Apply for PAR 20 266 Funding Number: PAR 20 266 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| NIDA Core "Center of Excellence" Grant Program (P30 Clinical Trial Optional) Apply for PAR 20 267 Funding Number: PAR 20 267 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Limited Competition: International Agency for Research on Cancer (IARC) Monographs Program (R01 Clinical Trial Not Allowed) Apply for RFA CA 20 045 Funding Number: RFA CA 20 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed) Apply for PAR 20 271 Funding Number: PAR 20 271 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed) Apply for PAR 20 276 Funding Number: PAR 20 276 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed) Apply for PAR 20 277 Funding Number: PAR 20 277 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| NCI Outstanding Investigator Award (R35 Clinical Trial Not Allowed) Apply for PAR 20 278 Funding Number: PAR 20 278 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Device-Based Treatments for Substance Use Disorders (UG3/UH3, Clinical Trial Optional) Apply for PAR 20 279 Funding Number: PAR 20 279 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Investigator-Initiated Research on Genetic Counseling Processes and Practices (R01, Clinical Trial Optional) Apply for RFA HG 20 048 Funding Number: RFA HG 20 048 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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