Opportunity Information: Apply for RFA EB 17 002
The BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01) opportunity (RFA-EB-17-002) is a National Institutes of Health (NIH) funding announcement under the NIH BRAIN Initiative focused on pushing human neuroscience forward by creating substantially improved, noninvasive brain imaging technologies. The core purpose is to fund the full development of entirely new or clearly next generation tools and methods for imaging the human brain that can produce transformative gains in what researchers can measure, map, and understand about brain structure and function. In practical terms, this announcement is aimed less at early exploration and more at building and delivering usable, working imaging capabilities that can be adopted by the broader research community within the BRAIN Initiative timeline described in the BRAIN 2025 scientific vision.
This FOA is positioned as a later-stage, full-scale development step rather than a seed or pilot mechanism. It explicitly represents the second stage of a broader technology development pipeline that began with earlier BRAIN-related solicitations (RFA-MH-14-217 and RFA-MH-15-200). That framing matters because it signals that applications should be beyond basic feasibility and ready for intensive engineering, integration, validation, and preparation for real-world research use. The expectation is that proposed projects will turn breakthrough concepts into deployable tools or robust methods, with clear milestones and an emphasis on delivering functional outcomes rather than only publishing incremental advances.
The award mechanism is a U01 cooperative agreement, meaning NIH is expected to have substantial involvement during the project period compared with a standard grant. Cooperative agreements typically imply coordinated project management, milestone-driven progress, and active interaction with NIH program staff to keep development aligned with program goals. The activity sits in the broad domain of health and research infrastructure (with the listing including education and health-related categories), and it is associated with multiple CFDA program numbers, reflecting its cross-institute relevance within NIH and the multi-disciplinary nature of neurotechnology development.
Eligibility is intentionally broad and includes a wide range of organization types: state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; and federally recognized tribal governments. It also includes tribal organizations that are not federally recognized, public and Indian housing authorities, nonprofits with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses. In addition, the FOA highlights other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This breadth reflects NIH’s intent to attract high-impact engineering and neuroscience teams wherever they are based and to encourage participation from institutions that broaden the diversity and geographic reach of the BRAIN technology ecosystem.
Key administrative details from the source data include an original closing date of February 1, 2017, and a creation date of October 21, 2016. While the source excerpt does not specify an award ceiling or the expected number of awards, the central message is clear: NIH is seeking ambitious, development-ready proposals that can produce next generation, noninvasive imaging tools or methods capable of substantially advancing human brain research on the BRAIN Initiative’s schedule.Apply for RFA EB 17 002
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2016-10-21.
- Applicants must submit their applications by 2017-02-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01) Apply for RFA NS 17 019 Funding Number: RFA NS 17 019 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Team-Research BRAIN Circuit Programs - TeamBCP (U19) Apply for RFA NS 17 018 Funding Number: RFA NS 17 018 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Projects - TargetedBCP (R01) Apply for RFA NS 17 014 Funding Number: RFA NS 17 014 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Revision Applications for U.S-South Africa Program for Collaborative Biomedical Research (R01) Apply for RFA AI 16 082 Funding Number: RFA AI 16 082 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Revision Applications for U.S.-South Africa Program for Collaborative Biomedical Research (U01) Apply for RFA AI 16 083 Funding Number: RFA AI 16 083 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH-DoD-VA Pain Management Collaboratory - Pragmatic Clinical Trials Demonstration Projects (UG3/UH3) Apply for RFA AT 17 001 Funding Number: RFA AT 17 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research To Address Sleep Disorders in the Context of Medical Rehabilitation (R01) Apply for PAR 17 163 Funding Number: PAR 17 163 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $499,999 |
| Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3) Apply for PAR 17 205 Funding Number: PAR 17 205 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44) Apply for PAR 17 201 Funding Number: PAR 17 201 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: New Concepts and Early - Stage Research for Large - Scale Recording and Modulation in the Nervous System (R21) Apply for RFA EY 17 002 Funding Number: RFA EY 17 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01) Apply for RFA MH 18 500 Funding Number: RFA MH 18 500 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01) Apply for RFA MH 18 505 Funding Number: RFA MH 18 505 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24) Apply for RFA NS 18 005 Funding Number: RFA NS 18 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Tools to target, identify and characterize non-neuronal cells in the brain (R01 Clinical Trial Not Allowed) Apply for RFA DA 18 018 Funding Number: RFA DA 18 018 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Opioid Use Disorder in Pregnancy (R01) Apply for RFA HD 18 036 Funding Number: RFA HD 18 036 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 - Clinical Trial Not Allowed) Apply for RFA NS 18 009 Funding Number: RFA NS 18 009 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trials Not Allowed) Apply for RFA EB 17 003 Funding Number: RFA EB 17 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01) (Clinical Trials Not Allowed) Apply for RFA EB 17 004 Funding Number: RFA EB 17 004 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed) Apply for RFA EB 17 005 Funding Number: RFA EB 17 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Advancing Translational and Clinical Probiotic/Prebiotic and Human Microbiome Research (R01 Clinical Trial Optional) Apply for PA 18 001 Funding Number: PA 18 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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